Macklott's pythons are known for their active and alert nature, and while they are hardy and relatively low-maintenance, they may be defensive when young or in new environments. With regular handling, they can become manageable pets for experienced reptile keepers. In the wild, they inhabit rocky outcrops, savannas, and forested areas, often seeking shelter in crevices and caves. Like other pythons, they are constrictors, feeding primarily on small mammals and birds.

Their unique coloration and manageable size make Macklott’s pythons an intriguing choice for snake enthusiasts who appreciate an active, inquisitive species but just remember that this one definitely has some spice to her!